Transcriptome analysis of the transdifferentiation of canine BMSCs into insulin producing cells.

ABSTRACT:

Background

Bone marrow mesenchymal stem cells are a potential resource for the clinical therapy of certain diseases. Canine, as a companion animal, living in the same space with human, is an ideal new model for human diseases research. Because of the high prevalence of diabetes, alternative transplantation islets resource (i.e. insulin producing cells) for diabetes treatment will be in urgent need, which makes our research on the transdifferentiation of Bone marrow mesenchymal stem cells into insulin producing cells become more important.

Result

In this study, we completed the transdifferentiation process and achieved the transcriptome profiling of five samples with two biological duplicates, namely, "BMSCs", "islets", "stage 1", "stage 2" and "stage 3", and the latter three

SUBMITTER: Wang J 

PROVIDER: S-EPMC7905582 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature