UTRN inhibits melanoma growth by suppressing p38 and JNK/c-Jun signaling pathways.

ABSTRACT:

Background

Utrophin (UTRN), as a tumor suppressor gene, is involved in various cancer progression. The function of UTRN in the melanoma process and the related molecular mechanisms are still unclear. Herein, we studied the function of UTRN in melanoma growth and the relevant molecular mechanisms.

Methods

Using the GEO database and UCSC Xena project, we compared the expression of UTRN in non-cancerous and melanoma tissues. Immunohistochemistry (IHC) staining, qRT-PCR and Western Blot (WB) were performed to evaluate UTRN expression in clinical samples. A total of 447 cases with UTRN expression data, patient characteristics and survival data were extracted from TCGA database and analyzed. After stable transduction and single cell cloning, the proliferation ability of A375 human

SUBMITTER: Zhou S 

PROVIDER: S-EPMC7905598 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature