Malawian children with fast-breathing pneumonia with and without comorbidities.

ABSTRACT:

Background

Due to high risk of mortality, children with comorbidities are typically excluded from trials evaluating pneumonia treatment. Understanding heterogeneity of outcomes among children with pneumonia and comorbidities is critical to ensuring appropriate treatment.

Methods

We explored whether the percentage of children with fast-breathing pneumonia cured at Day 14 was lower among those with selected comorbidities enrolled in a prospective observational study than among those enrolled in a concurrent randomized controlled trial evaluating treatment with amoxicillin in Lilongwe, Malawi.

Results

Among 79 children with fast-breathing pneumonia in the prospective observational cohort, 57 (72.2%) had HIV infection/exposure, 20 (25.3%) had malaria, 2 (2.5%) had severe

SUBMITTER: Ginsburg AS 

PROVIDER: S-EPMC7905626 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature