Efficacy, acceptability, and safety of antidepressants for low back pain: a systematic review and meta-analysis.

ABSTRACT:

Background

Antidepressant medicines are used to manage symptoms of low back pain. The efficacy, acceptability, and safety of antidepressant medicines for low back pain (LBP) are not clear. We aimed to evaluate the efficacy, acceptability, and safety of antidepressant medicines for LBP.

Methods

We searched CENTRAL, MEDLINE, Embase, CINAHL, ClinicalTrials.gov , the EU Clinical Trials Register, and the WHO International Clinical Trial Registry Platform from inception to May 2020. We included published and trial registry reports of RCTs that allocated adult participants with LBP to receive an antidepressant medicine or a placebo medicine. Pairs of authors independently extracted data in duplicate. We extracted participant characteristics, study sample size, outcome values, and m

SUBMITTER: Ferraro MC 

PROVIDER: S-EPMC7905649 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature