Effect of reductions in amyloid levels on cognitive change in randomized trials: instrumental variable meta-analysis.

ABSTRACT:

Objective

To evaluate trials of drugs that target amyloid to determine whether reductions in amyloid levels are likely to improve cognition.

Design

Instrumental variable meta-analysis.

Setting

14 randomized controlled trials of drugs for the prevention or treatment of Alzheimer's disease that targeted an amyloid mechanism, identified from ClinicalTrials.gov.

Population

Adults enrolled in randomized controlled trials of amyloid targeting drugs. Inclusion criteria for trials vary, but typically include adults aged 50 years or older with a diagnosis of mild cognitive impairment or Alzheimer's disease, and amyloid positivity at baseline.

Main outcome measures

Analyses included trials for which information could be obtained on both change in brain amyloid lev

SUBMITTER: Ackley SF 

PROVIDER: S-EPMC7905687 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature