A novel fluorescent cardiac imaging system for preclinical intraoperative angiography.

ABSTRACT:

Background

Intraoperative coronary angiography can tremendously reduce early coronary bypass graft failures. Fluorescent cardiac imaging provides an advanced method for intraoperative observation and real-time quantitation of blood flow with high resolution.

Methods

We devised a system comprised of an LED light source, special filters, lenses and a detector for preclinical coronary artery angiography. The optical setup was implemented by using two achromatic doublet lenses, two positive meniscus lenses, a band-pass filter, a pinhole and a CCD sensor. The setup was optimized by Zemax software. Optical design was further challenged to obtain more parallel light beams, less diffusion and higher resolutions to levels as small as arterioles. Ex vivo rat hearts were prepared and c

SUBMITTER: Mashalchi S 

PROVIDER: S-EPMC7905866 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature