Fast and Accurate Nanoparticle Characterization Using Deep-Learning-Enhanced Off-Axis Holography.

ABSTRACT: Characterization of suspended nanoparticles in their native environment plays a central role in a wide range of fields, from medical diagnostics and nanoparticle-enhanced drug delivery to nanosafety and environmental nanopollution assessment. Standard optical approaches for nanoparticle sizing assess the size via the diffusion constant and, as a consequence, require long trajectories and that the medium has a known and uniform viscosity. However, in most biological applications, only short trajectories are available, while simultaneously, the medium viscosity is unknown and tends to display spatiotemporal variations. In this work, we demonstrate a label-free method to quantify not only size but also refractive index of individual subwavelength particles using 2 orders of magnitude s

SUBMITTER: Midtvedt B 

PROVIDER: S-EPMC7905872 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature