A sonosensitiser-based polymeric nanoplatform for chemo-sonodynamic combination therapy of lung cancer.

ABSTRACT:

Background

Lung cancer is the most common type of tumour worldwide. Its relative lethality is considerably high. However, since the tumour tissues are located deep within the human body, traditional technologies, such as photodynamic therapy, do not have the desired effect. Sonosensitisers can penetrate deeply into tissues, and sonodynamic therapy (SDT) effectively inhibits tumours by generating reactive oxygen species. Ultrasound can also penetrate deeply, with a favourable tumour inhibition effect.

Results

A redox/ultrasound-responsive Rhein-chondroitin sulphate-based nano-preparation encapsulating docetaxel was fabricated. The nanoparticles displayed increased cellular uptake with quick drug release, good stability, and a monodispersed form in the physiological environmen

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC7905889 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature