Sex-dependent liver cancer xenograft models for predicting clinical data in the evaluation of anticancer drugs.

ABSTRACT:

Background

The incidence and mortality of liver cancer show a great difference between the sexes. We established sex-dependent liver cancer xenograft models and investigated whether such sex-dependent models could be used to simultaneously evaluate the therapeutic and adverse effects of anticancer drugs for drug screening.

Results

In the in-vitro test, the cytotoxicity of anticancer drugs (cisplatin, 5-fluorouracil, and doxorubicin) was compared between male- and female-derived liver cancer cell lines. Cisplatin and 5-fluorouracil exhibited cytotoxicity without sex-difference, but doxorubicin showed dose-dependently significant cytotoxicity only in male-derived cells. Our results showed a strong correlation between preclinical and clinical data with the use of sex-dependent

SUBMITTER: Oh S 

PROVIDER: S-EPMC7905914 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature