Virus-like particles: preparation, immunogenicity and their roles as nanovaccines and drug nanocarriers.

ABSTRACT: Virus-like particles (VLPs) are virus-derived structures made up of one or more different molecules with the ability to self-assemble, mimicking the form and size of a virus particle but lacking the genetic material so they are not capable of infecting the host cell. Expression and self-assembly of the viral structural proteins can take place in various living or cell-free expression systems after which the viral structures can be assembled and reconstructed. VLPs are gaining in popularity in the field of preventive medicine and to date, a wide range of VLP-based candidate vaccines have been developed for immunization against various infectious agents, the latest of which is the vaccine against SARS-CoV-2, the efficacy of which is being evaluated. VLPs are highly immunogenic and are able t

SUBMITTER: Nooraei S 

PROVIDER: S-EPMC7905985 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature