Physical activity offsets genetic risk for incident depression assessed via electronic health records in a biobank cohort study.

ABSTRACT:

Background

Physical activity is increasingly recognized as an important modifiable factor for depression. However, the extent to which individuals with stable risk factors for depression, such as high genetic vulnerability, can benefit from the protective effects of physical activity, remains unknown. Using a longitudinal biobank cohort integrating genomic data from 7,968 individuals of European ancestry with high-dimensional electronic health records and lifestyle survey responses, we examined whether physical activity was prospectively associated with reduced risk for incident depression in the context of genetic vulnerability.

Methods

We identified individuals with incident episodes of depression, based on two or more diagnostic billing codes for a depressive disorder wit

SUBMITTER: Choi KW 

PROVIDER: S-EPMC7905987 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature