The gut microbiome distinguishes mortality in trauma patients upon admission to the emergency department.

ABSTRACT:

Background

Traumatic injury can lead to a compromised intestinal epithelial barrier, decreased gut perfusion, and inflammation. While recent studies indicate that the gut microbiome (GM) is altered early following traumatic injury, the impact of GM changes on clinical outcomes remains unknown. Our objective of this follow-up study was to determine if the GM is associated with clinical outcomes in critically injured patients.

Methods

We conducted a prospective, observational study in adult patients (N = 67) sustaining severe injury admitted to a level I trauma center. Fecal specimens were collected on admission to the emergency department, and microbial DNA from all samples was analyzed using the Quantitative Insights Into Microbial Ecology pipeline and compared against the G

SUBMITTER: Burmeister DM 

PROVIDER: S-EPMC7905995 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature