So-called bifocal tumors with diabetes insipidus and negative tumor markers: are they all germinoma?

ABSTRACT:

Background

The Delphi consensus statements on the management of germ cell tumors (GCTs) failed to reach agreements on the statement that the cases with (i) pineal and neurohypophyseal bifocal lesion, (ii) with diabetes insipidus, and (iii) with negative tumor markers can be diagnosed as germinoma without histological verification. To answer this, multicenter retrospective analysis was performed.

Methods

A questionnaire on clinical findings, histological diagnosis, and details of surgical procedures was sent to 86 neurosurgical and 35 pediatrics departments in Japan.

Results

Fifty-one institutes reported 132 cases that fulfilled the 3 criteria. Tissue sampling was performed in 91 cases from pineal (n = 44), neurohypophyseal (n = 32), both (n = 6), and distant (n = 9) l

SUBMITTER: Kanamori M 

PROVIDER: S-EPMC7906060 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature