DNA methylation based glioblastoma subclassification is related to tumoral T-cell infiltration and patient survival.

ABSTRACT:

Background

Histologically classified glioblastomas (GBM) can have different clinical behavior and response to therapy, for which molecular subclassifications have been proposed. We evaluated the relationship of epigenetic GBM subgroups with immune cell infiltrations, systemic immune changes during radiochemotherapy, and clinical outcome.

Methods

450K genome-wide DNA methylation was assessed on tumor tissue from 93 patients with newly diagnosed GBM, treated with standard radiochemotherapy and experimental immunotherapy. Tumor infiltration of T cells, myeloid cells, and Programmed cell death protein 1 (PD-1) expression were evaluated. Circulating immune cell populations and selected cytokines were assessed on blood samples taken before and after radiochemotherapy.

Results</

SUBMITTER: Dejaegher J 

PROVIDER: S-EPMC7906065 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature