Temporal changes in the epidemiology, management, and outcome from acute respiratory distress syndrome in European intensive care units: a comparison of two large cohorts.

ABSTRACT:

Background

Mortality rates for patients with ARDS remain high. We assessed temporal changes in the epidemiology and management of ARDS patients requiring invasive mechanical ventilation in European ICUs. We also investigated the association between ventilatory settings and outcome in these patients.

Methods

This was a post hoc analysis of two cohorts of adult ICU patients admitted between May 1-15, 2002 (SOAP study, n = 3147), and May 8-18, 2012 (ICON audit, n = 4601 admitted to ICUs in the same 24 countries as the SOAP study). ARDS was defined retrospectively using the Berlin definitions. Values of tidal volume, PEEP, plateau pressure, and FiO₂ corresponding to the most abnormal value of arterial PO₂ were recorded prospectively every 24 h. In both stud

SUBMITTER: Sakr Y 

PROVIDER: S-EPMC7906083 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature