Transcranial ultrasound pulse stimulation reduces cortical atrophy in Alzheimer's patients: A follow-up study.

ABSTRACT:

Introduction

Ultrasound for the brain is a revolutionary therapeutic concept. The first clinical data indicate that 2-4 weeks of therapy with transcranial pulse stimulation (TPS) improve functional networks and cognitive performance of Alzheimer's disease (AD) patients for up to 3 months. No data currently exist on possible benefits concerning brain morphology, namely the cortical atrophy characteristic of AD.

Methods

We performed a pre-/post-therapy analysis of cortical thickness in a group of N = 17 AD patients.

Results

We found a significant correlation between neuropsychological improvement and cortical thickness increase in AD-critical brain areas.

Discussion

AD patients who benefit from TPS appear to manifest reduced cortical atrophy within the default mo

SUBMITTER: Popescu T 

PROVIDER: S-EPMC7906128 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature