High expression of RRM2 as an independent predictive factor of poor prognosis in patients with lung adenocarcinoma.

ABSTRACT: Ribonucleotide reductase subunit M2 may play a role as a potential prognostic biomarker in several cancers. In this study, we evaluated whether RRM2 gene expression is associated with the prognosis of patients with lung adenocarcinoma (LUAD) using publicly available data from The Cancer Genome Atlas (TCGA). Wilcoxon signed-rank test and logistic regression were performed to evaluate the association between RRM2 expression and clinical features in patients with LUAD. Kaplan-Meier and Cox regression methods were used to examine the effect of RRM2 expression level in the overall survival, and a nomogram was performed to illustrate the correlation between the RRM2 gene expression and the risk of LUAD. TCGA data set was used for gene set enrichment analysis (GSEA). W

SUBMITTER: Jin CY 

PROVIDER: S-EPMC7906179 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature