Effect of therapeutic hypothermia on renal and myocardial function in asphyxiated (near) term neonates: A systematic review and meta-analysis.

ABSTRACT:

Background

Therapeutic hypothermia (TH) is a well-established neuroprotective therapy applied in (near) term asphyxiated infants. However, little is known regarding the effects of TH on renal and/or myocardial function.

Objectives

To describe the short- and long-term effects of TH on renal and myocardial function in asphyxiated (near) term neonates.

Methods

An electronic search strategy incorporating MeSH terms and keywords was performed in October 2019 and updated in June 2020 using PubMed and Cochrane databases. Inclusion criteria consisted of a RCT or observational cohort design, intervention with TH in a setting of perinatal asphyxia and available long-term results on renal and myocardial function. We performed a meta-analysis and heterogeneity and sensitivity ana

SUBMITTER: van Wincoop M 

PROVIDER: S-EPMC7906340 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature