Whole genome genetic variation and linkage disequilibrium in a diverse collection of Listeria monocytogenes isolates.

ABSTRACT: We performed whole-genome multi-locus sequence typing for 2554 genes in a large and heterogenous panel of 180 Listeria monocytogenes strains having diverse geographical and temporal origins. The subtyping data was used for characterizing genetic variation and evaluating patterns of linkage disequilibrium in the pan-genome of L. monocytogenes. Our analysis revealed the presence of strong linkage disequilibrium in L. monocytogenes, with ~99% of genes showing significant non-random associations with a large majority of other genes in the genome. Twenty-seven loci having lower levels of association with other genes were considered to be potential "hot spots" for horizontal gene transfer (i.e., recombination via conjugation, transduction, and/or transformation). The patterns of linkage disequil

SUBMITTER: Louha S 

PROVIDER: S-EPMC7906370 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature