Identification of UBE2C as hub gene in driving prostate cancer by integrated bioinformatics analysis.

ABSTRACT:

Background

The aim of this study was to identify novel genes in promoting primary prostate cancer (PCa) progression and to explore its role in the prognosis of prostate cancer.

Methods

Four microarray datasets containing primary prostate cancer samples and benign prostate samples were downloaded from Gene Expression Omnibus (GEO), then differentially expressed genes (DEGs) were identified by R software (version 3.6.2). Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) were performed to identify the function of DEGs. Using STRING and Cytoscape (version 3.7.1), we constructed a protein-protein interaction (PPI) network and identified the hub gene of prostate cancer. Clinical data on GSE70770 and TCGA was collected to show the role of hub gene in prostate ca

SUBMITTER: Wang Y 

PROVIDER: S-EPMC7906463 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature