Neuropsychological Test Performance and MRI Markers of Dementia Risk: Reducing Education Bias.

ABSTRACT:

Background

To use neuropsychological assessments for studying the underlying disease processes contributing to dementia, it is crucial that they correspond to magnetic resonance imaging (MRI)-based measures of dementia, regardless of educational level.

Methods

French 3-City Dijon MRI study cohort members (n=1782) with assessments of white matter lesion volume (WMLV), hippocampal volume (HCV), and cerebrospinal fluid volume (CSFV), and 6 waves of neuropsychological assessments over 11 years, including Mini-Mental State Examination (MMSE), plus 5 other tests combined using a Z-score or item-response theory (IRT-cognition) comprised the study cohort. We evaluated, testing interactions, whether education modified associations of MRI markers with intercept or rate of change of MM

SUBMITTER: Walter S 

PROVIDER: S-EPMC7906575 | biostudies-literature | 2019 Jul-Sep

REPOSITORIES: biostudies-literature