An integrative model of cardiometabolic traits identifies two types of metabolic syndrome.

ABSTRACT: Human diseases arise in a complex ecosystem composed of disease mechanisms and the whole-body state. However, the precise nature of the whole-body state and its relations with disease remain obscure. Here we map similarities among clinical parameters in normal physiological settings, including a large collection of metabolic, hemodynamic, and immune parameters, and then use the mapping to dissect phenotypic states. We find that the whole-body state is faithfully represented by a quantitative two-dimensional model. One component of the whole-body state represents 'metabolic syndrome' (MetS) - a conventional way to determine the cardiometabolic state. The second component is decoupled from the classical MetS, suggesting a novel 'non-classical MetS' that is characterized by dozens of paramete

SUBMITTER: Frishberg A 

PROVIDER: S-EPMC7906604 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature