Age-Related Compensatory Reconfiguration of PFC Connections during Episodic Memory Retrieval.

ABSTRACT: During demanding cognitive tasks, older adults (OAs) frequently show greater prefrontal cortex (PFC) activity than younger adults (YAs). This age-related increase in PFC activity is often associated with enhanced cognitive performance, suggesting functional compensation. However, the brain is a complex network of interconnected regions, and it is unclear how network connectivity of PFC regions differs for OAs versus YAs. To investigate this, we examined the age-related difference on the functional brain networks mediating episodic memory retrieval. YAs and OAs participants encoded and recalled visual scenes, and age-related differences in network topology during memory retrieval were investigated as a function of memory performance. We measured both changes in functional integration and re

SUBMITTER: Deng L 

PROVIDER: S-EPMC7906775 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature