Effects of Age on Prestimulus Neural Activity Predictive of Successful Memory Encoding: An fMRI Study.

ABSTRACT: Prestimulus subsequent memory effects (SMEs)-differences in neural activity preceding the onset of study items that are predictive of later memory performance-have consistently been reported in young adults. The present functional magnetic resonance imaging experiment investigated potential age-related differences in prestimulus SMEs. During study, healthy young and older participants made one of two semantic judgments on images, with the judgment signaled by a preceding cue. In test phase, participants first made an item recognition judgment and, for each item judged old, a source memory judgment. Age-invariant prestimulus SMEs were observed in left dorsomedial prefrontal cortex, left hippocampus, and right subgenual cortex. In each case, the effects reflected lower blood oxygen level dep

SUBMITTER: Liu ES 

PROVIDER: S-EPMC7906785 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature