A Large Mammalian Model of Myocardial Regeneration After Myocardial Infarction in Fetal Sheep.

ABSTRACT: Objective: Ischemic heart disease accounts for over 20% of all deaths worldwide. As the global population faces a rising burden of chronic diseases, such as hypertension, hyperlipidemia, and diabetes, the prevalence of heart failure due to ischemic heart disease is estimated to increase. We sought to develop a model that may more accurately identify therapeutic targets to mitigate the development of heart failure following myocardial infarction (MI). Approach: Having utilized fetal large mammalian models of scarless wound healing, we proposed a fetal ovine model of myocardial regeneration after MI. Results: Use of this model has identified critical pathways in the mammalian response to MI, which are differentially activated in the regenerative, fetal mammalian response

SUBMITTER: Hodges MM 

PROVIDER: S-EPMC7906869 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature