Reduced lipolysis in lipoma phenocopies lipid accumulation in obesity.

ABSTRACT:

Background

Elucidation of lipid metabolism and accumulation mechanisms is of paramount importance to understanding obesity and unveiling therapeutic targets. In vitro cell models have been extensively used for these purposes, yet, they do not entirely reflect the in vivo setup. Conventional lipomas, characterized by the presence of mature adipocytes and increased adipogenesis, could overcome the drawbacks of cell cultures. Also, they have the unique advantage of easily accessible matched controls in the form of subcutaneous adipose tissue (SAT) from the same individual. We aimed to determine whether lipomas are a good model to understand lipid accumulation.

Methods

We histologically compared lipomas and control SAT, followed by assessment of the lipidome using high-resolutio

SUBMITTER: Le Duc D 

PROVIDER: S-EPMC7906903 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature