Cytophaga hutchinsonii SprA and SprT Are Essential Components of the Type IX Secretion System Required for Ca²⁺ Acquisition, Cellulose Degradation, and Cell Motility.

ABSTRACT: The type IX secretion system (T9SS) is a novel protein secretion system, which is found in and confined to the phylum Bacteroidetes. T9SS is involved in the secretion of virulence factors, cell surface adhesins, and complex biopolymer degrading enzymes to the cell surface or extracellular medium. Cytophaga hutchinsonii is a widely distributed bacterium, which is able to efficiently digest cellulose and rapidly glide along the solid surfaces. C. hutchinsonii has a full set of orthologs of T9SS components. However, the functions of most homologous proteins have not been verified. In C. hutchinsonii, CHU_0029 and CHU_2709 are similar in sequence to Flavobacterium johnsoniae T9SS components SprA and SprT, respectively. In this study, the single deletio

SUBMITTER: Gao L 

PROVIDER: S-EPMC7906972 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature