Place Cells in Head-Fixed Mice Navigating a Floating Real-World Environment.

ABSTRACT: The hippocampal place cell system in rodents has provided a major paradigm for the scientific investigation of memory function and dysfunction. Place cells have been observed in area CA1 of the hippocampus of both freely moving animals, and of head-fixed animals navigating in virtual reality environments. However, spatial coding in virtual reality preparations has been observed to be impaired. Here we show that the use of a real-world environment system for head-fixed mice, consisting of an air-floating track with proximal cues, provides some advantages over virtual reality systems for the study of spatial memory. We imaged the hippocampus of head-fixed mice injected with the genetically encoded calcium indicator GCaMP6s while they navigated circularly constrained or open environments on t

SUBMITTER: Go MA 

PROVIDER: S-EPMC7906988 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature