The impact of homocysteine on the risk of coronary artery diseases in individuals with diabetes: a Mendelian randomization study.

ABSTRACT:

Aims

Observational studies have reported that homocysteine (Hcy) is associated with an increased risk of coronary artery disease (CAD) in individuals with diabetes, though controversy remains. The present study aimed to investigate the causal association between Hcy and CAD in individuals with diabetes.

Methods

A 2-sample Mendelian randomization (MR) study was designed to infer causality. Genetic summary data on the association of single nucleotide polymorphisms (SNPs) with Hcy were extracted from the hitherto largest genome-wide association study (GWAS) of up to 44,147 individuals of European ancestry. SNP-CAD data were obtained from another recently published GWAS which included 15,666 individuals with diabetes (3,968 CAD cases, 11,696 controls). The fixed-effects inverse

SUBMITTER: Xu T 

PROVIDER: S-EPMC7907016 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature