Metabolomic profiling of patients with high gradient aortic stenosis undergoing transcatheter aortic valve replacement.

ABSTRACT:

Aim

Aim of our study was to evaluate metabolic changes in patients with aortic stenosis (AS) before and after transcatheter aortic valve replacement (TAVR) and to assess whether this procedure reverses metabolomic alterations.

Methods

188 plasma metabolites of 30 patients with severe high-gradient aortic valve stenosis (pre-TAVR and 6 weeks post-TAVR) as well as 20 healthy controls (HC) were quantified by liquid chromatography tandem mass spectrometry. Significantly altered metabolites were then correlated to an extensive patient database of clinical parameters at the time of measurement.

Results

Out of the determined metabolites, 26.6% (n = 50) were significantly altered in patients with AS pre-TAVR compared to HC. In detail, 5/40 acylcarnitines as well as 10/42 amin

SUBMITTER: Haase D 

PROVIDER: S-EPMC7907030 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature