Effects of oral moisturizing gel containing propolis following head and neck radiotherapy: randomized controlled pilot trial.

ABSTRACT:

Aim

Topical administration of oral gel may reduce radiotherapy-related oral complications. The aim of this study was to examine clinical and microbiological effects of self-administration of different gel formulations to oral mucosa in head and neck cancer patients.

Materials and methods

Twenty-seven subjects were recruited from outpatients who underwent radiotherapy of at least 50 Gy to the head and neck area. They were randomly assigned to oral gel with the following different ingredients: placebo, chlorhexidine, curry leaf, propolis, and turmeric. Before and after intervention, oral symptoms were evaluated, and nine oral pathogens in saliva were also quantified using real-time PCR.

Results

Twenty-five subjects completed the study and their data were analyzed. The n

SUBMITTER: Nakao R 

PROVIDER: S-EPMC7907078 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature