Correlation between circulating interleukin-18 level and systemic lupus erythematosus: a meta-analysis.

ABSTRACT: This study is a meta-analysis aimed at pooling reported data and clarifying the association between circulating level of interleukin-18 and systemic lupus erythematosus (SLE). We searched medical databases including Medline/Pubmed, Embase, Scopus, The Cochrane Library, and Web of Science thoroughly to obtain all related articles published before July 15th, 2020. We pooled computed standardized mean difference (SMD) and its 95% confidence interval using STATA 13.0 and exhibited in the form of forest graph. Meta-regression and subgroup analysis were also performed to explore the source of heterogeneity. Publication bias was first evaluated by the symmetry of the funnel plot and then Egger's linear regression test. Thirty eligible studies from eighteen regions were finally included and the re

SUBMITTER: Xiang M 

PROVIDER: S-EPMC7907126 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature