Choriocapillaris microvasculature dysfunction in systemic hypertension.

ABSTRACT: We examined the choriocapillaris microvasculature using a non-invasive swept-source optical coherence tomography angiography (SS-OCTA) in 41 healthy controls and 71 hypertensive patients and determined possible correlations with BP and renal parameters. BP levels, serum creatinine and urine microalbumin/creatinine ratio (MCR) specimens were collected. The estimated glomerular filtration rate (eGFR) was calculated based on CKD-EPI Creatinine Equation. The main outcome was choriocapillaris flow deficits (CFD) metrics (density, size and numbers). The CFD occupied a larger area and were fewer in number in the hypertensive patients with poor BP control (407 ± 10 µm²; 3260 ± 61) compared to the hypertensives with good BP control (369 ± 5 µm²; 3551 ± 41) and healthy controls

SUBMITTER: Chua J 

PROVIDER: S-EPMC7907127 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature