Flow velocity quantification by exploiting the principles of the Doppler effect and magnetic particle imaging.

ABSTRACT: Changes in blood flow velocity play a crucial role during pathogenesis and progression of cardiovascular diseases. Imaging techniques capable of assessing flow velocities are clinically applied but are often not accurate, quantitative, and reliable enough to assess fine changes indicating the early onset of diseases and their conversion into a symptomatic stage. Magnetic particle imaging (MPI) promises to overcome these limitations. Existing MPI-based techniques perform velocity estimation on the reconstructed images, which restricts the measurable velocity range. Therefore, we developed a novel velocity quantification method by adapting the Doppler principle to MPI. Our method exploits the velocity-dependent frequency shift caused by a tracer motion-induced modulation of the emitted signa

SUBMITTER: Pantke D 

PROVIDER: S-EPMC7907137 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature