Signatures of white-matter microstructure degradation during aging and its association with cognitive status.

ABSTRACT: Previous studies have shown an association between cognitive decline and white matter integrity in aging. This led to the formulation of a "disconnection hypothesis" in the aging-brain, which states that the disruption in cortical network communication may explain the cognitive decline during aging. Although some longitudinal studies have already investigated the changes occurring in white matter microstructure, most focused on specific white matter tracts. Our study aims to characterize the longitudinal whole-brain signatures of white matter microstructural change during aging. Furthermore, we assessed the relationship between distinct longitudinal alterations in white matter integrity and cognition. White matter microstructural properties were estimated from diffusion magnetic resonance

SUBMITTER: Coelho A 

PROVIDER: S-EPMC7907273 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature