The Michigan Retinal Degeneration Questionnaire: A Patient-Reported Outcome Instrument for Inherited Retinal Degenerations.

ABSTRACT:

Purpose

To create a psychometrically validated patient-reported outcome measure for inherited retinal degenerations.

Design

Qualitative and quantitative patient-reported outcome (PROs) questionnaire development using item response theory validation.

Methods

One hundred twenty-eight patients with a diagnosis of an inherited retinal degeneration at the Kellogg Eye Center (University of Michigan) were recruited and administered a 166-item questionnaire comprising 7 expert-defined domains. The questionnaire was re-administered 4-16 days later to a subset of 25 participants to assess test-retest variability. Graded response models were fit by Cai's Metropolis-Hastings Robbins-Monro algorithm using the R (version 3.6.3) package mirt. Model data were fit to assess questionna

SUBMITTER: Lacy GD 

PROVIDER: S-EPMC7907279 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature