Dj1 deficiency protects against atherosclerosis with anti-inflammatory response in macrophages.

ABSTRACT: Inflammation is a key contributor to atherosclerosis with macrophages playing a pivotal role through the induction of oxidative stress and cytokine/chemokine secretion. DJ1, an anti-oxidant protein, has shown to paradoxically protect against chronic and acute inflammation. However, the role of DJ1 in atherosclerosis remains elusive. To assess the role of Dj1 in atherogenesis, we generated whole-body Dj1-deficient atherosclerosis-prone Apoe null mice (Dj1^-/-Apoe^-/-). After 21 weeks of atherogenic diet, Dj1^-/- Apoe^-/-mice were protected against atherosclerosis with significantly reduced plaque macrophage content. To assess whether haematopoietic or parenchymal Dj1 contributed to atheroprotection in Dj1-deficient mice, we performed bone-marrow (BM)

SUBMITTER: Sivasubramaniyam T 

PROVIDER: S-EPMC7907332 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature