Exploring the conservation of Alzheimer-related pathways between H. sapiens and C. elegans: a network alignment approach.

ABSTRACT: Alzheimer disease (AD) is a neurodegenerative disorder with an -as of yet- unclear etiology and pathogenesis. Research to unveil disease processes underlying AD often relies on the use of neurodegenerative disease model organisms, such as Caenorhabditis elegans. This study sought to identify biological pathways implicated in AD that are conserved in Homo sapiens and C. elegans. Protein-protein interaction networks were assembled for amyloid precursor protein (APP) and Tau in H. sapiens-two proteins whose aggregation is a hallmark in AD-and their orthologs APL-1 and PTL-1 for C. elegans. Global network alignment was used to compare these networks and determine similar, likely conserved, network regions. This comparison revealed that two prominent pathways, the APP-processing and the Tau-pho

SUBMITTER: Apostolakou AE 

PROVIDER: S-EPMC7907373 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature