Transcriptomic signatures for diagnosing tuberculosis in clinical practice: a prospective, multicentre cohort study.

ABSTRACT:

Background

Blood transcriptomic signatures for diagnosis of tuberculosis have shown promise in case-control studies, but none have been prospectively designed or validated in adults presenting with the full clinical spectrum of suspected tuberculosis, including extrapulmonary tuberculosis and common differential diagnoses that clinically resemble tuberculosis. We aimed to evaluate the diagnostic accuracy of transcriptomic signatures in patients presenting with clinically suspected tuberculosis in routine practice.

Methods

The Validation of New Technologies for Diagnostic Evaluation of Tuberculosis (VANTDET) study was nested within a prospective, multicentre cohort study in secondary care in England (IDEA 11/H0722/8). Patients (aged ≥16 years) suspected of having tuberculosis

SUBMITTER: Hoang LT 

PROVIDER: S-EPMC7907671 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature