Association of Risk-Reducing Salpingo-Oophorectomy With Breast Cancer Risk in Women With BRCA1 and BRCA2 Pathogenic Variants.

ABSTRACT:

Importance

Women with pathogenic variants in BRCA1 and BRCA2 are at high risk of developing breast and ovarian cancers. They usually undergo intensive cancer surveillance and may also consider surgical interventions, such as risk-reducing mastectomy or risk-reducing salpingo-oophorectomy (RRSO). Risk-reducing salpingo-oophorectomy has been shown to reduce ovarian cancer risk, but its association with breast cancer risk is less clear.

Objective

To assess the association of RRSO with the risk of breast cancer in women with BRCA1 and BRCA2 pathogenic variants.

Design, setting, and participants

This case series included families enrolled in the Breast Cancer Family Registry between 1996 and 2000 that carried an inherited pathogenic variant in BRCA1 (498 families) or BRCA2

SUBMITTER: Choi YH 

PROVIDER: S-EPMC7907985 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature