Aerosol drug delivery to spontaneously-breathing preterm neonates: lessons learned.

ABSTRACT: Delivery of medications to preterm neonates receiving non-invasive ventilation (NIV) represents one of the most challenging scenarios for aerosol medicine. This challenge is highlighted by the undersized anatomy and the complex (patho)physiological characteristics of the lungs in such infants. Key physiological restraints include low lung volumes, low compliance, and irregular respiratory rates, which significantly reduce lung deposition. Such factors are inherent to premature birth and thus can be regarded to as the intrinsic factors that affect lung deposition. However, there are a number of extrinsic factors that also impact lung deposition: such factors include the choice of aerosol generator and its configuration within the ventilation circuit, the drug formulation, the aerosol partic

SUBMITTER: Bianco F 

PROVIDER: S-EPMC7908012 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature