Metal Nanoparticles/MoS₂ Surface-Enhanced Raman Scattering-Based Sandwich Immunoassay for α-Fetoprotein Detection.

ABSTRACT: The detection of cancer biomarkers at an early stage of tumor development is vital for effective diagnosis and treatment of cancer. Current diagnostic tools can often detect cancer only when the biomarker levels are already too high, so that the tumors have spread and treatments are less effective. It is urgent therefore to develop highly sensitive assays for the detection of such biomarkers at the lowest possible concentration. In this context, we developed a sandwich immunoassay based on surface-enhanced Raman scattering (SERS) for the ultrasensitive detection of α-fetoprotein (AFP), which is typically present in human serum as a biomarker indicative of early stages of hepatocellular carcinoma. In the immunoassay design, molybdenum disulfide (MoS₂) modified with a monoclonal a

SUBMITTER: Er E 

PROVIDER: S-EPMC7908013 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature