IL-17F Gene rs763780 and IL-17A rs2275913 Polymorphisms in Patients with Periodontitis.

ABSTRACT: Background: Periodontitis (PD) is a chronic inflammatory disease that can eventually lead to tooth loss. Genetic and environmental factors such as smoking are involved in the pathogenesis of PD. The development of PD is potentiated by various pathogens that induce an immune response leading to the production of cytokines, such as interleukin (IL)-17. The synthesis of IL-17 is influenced genetically. The polymorphisms in IL-17 gene may affect the synthesis of IL-17. The aim of this study was to examine the association between the IL-17F rs763780 and IL-17A rs2275913 polymorphisms and PD in non-smoking and smoking patients to check if these polymorphisms could be a risk factor for PD. Methods: The study enrolled 200 patients with PD (130 non-smokers and 70

SUBMITTER: Mazurek-Mochol M 

PROVIDER: S-EPMC7908462 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature