Polydatin Beneficial Effects in Zebrafish Larvae Undergoing Multiple Stress Types.

ABSTRACT: Polydatin is a polyphenol, whose beneficial properties, including anti-inflammatory and antioxidant activity, have been largely demonstrated. At the same time, copper has an important role in the correct organism homeostasis and alteration of its concentration can induce oxidative stress. In this study, the efficacy of polydatin to counteract the stress induced by CuSO₄ exposure or by caudal fin amputation was investigated in zebrafish larvae. The study revealed that polydatin can reduced the stress induced by a 2 h exposure to 10 µM CuSO₄ by lowering the levels of il1b and cxcl8b.1 and reducing neutrophils migration in the head and along the lateral line. Similarly, polydatin administration reduced the number of neutrophils in the area of fin cut. In ad

SUBMITTER: Pessina A 

PROVIDER: S-EPMC7908490 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature