Immune subtyping for pancreatic cancer with implication in clinical outcomes and improving immunotherapy.

ABSTRACT:

Background

Emerging evidence has shown that intra-tumor immune features are associated with response to immune checkpoint blockade (ICB) therapy. Accordingly, patient stratification is needed for identifying target patients and designing strategies to improve the efficacy of ICB therapy. We aimed to depict the specific immune features of patients with pancreatic cancer and explore the implication of immune diversity in prognostic prediction and individualized immunotherapy.

Methods

From transcriptional profiles of 383 tumor samples in TCGA, ICGC, and GEO database, robust immune subtypes which had different response immunotherapy, including ICB therapy, were identified by consensus clustering with five gene modules. DEGs analysis and tumor microarray were used to screen and d

SUBMITTER: Liu J 

PROVIDER: S-EPMC7908647 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature