Lack of CD34 delays bacterial endotoxin-induced lung inflammation.

ABSTRACT:

Background

CD34, a pan-selectin binding protein when glycosylated, has been shown to be involved in leukocyte migration to the site of inflammation. However, only one report is available on the expression and role of CD34 in neutrophil recruitment during acute lung inflammation.

Methods

We proceeded to study the role of CD34 in lung neutrophil migration using mouse model of endotoxin induced acute lung inflammation and studied over multiple time points, in generic CD34 knock-out (KO) strain.

Results

While there was no difference in BAL total or differential leukocyte counts, lung MPO content was lower in LPS exposed KO compared to WT group at 3 h time-point (p = 0.0308). The MPO levels in CD34 KO mice begin to rise at 9 h (p = 0.0021), as opposed to an early 3 h rise

SUBMITTER: Aulakh GK 

PROVIDER: S-EPMC7908703 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature