Distribution of chimeric antigen receptor-modified T cells against CD19 in B-cell malignancies.

ABSTRACT:

Background

The unprecedented efficacy of chimeric antigen receptor T (CAR-T) cell immunotherapy of CD19⁺ B-cell malignancies has opened a new and useful way for the treatment of malignant tumors. Nonetheless, there are still formidable challenges in the field of CAR-T cell therapy, such as the biodistribution of CAR-T cells in vivo.

Methods

NALM-6, a human B-cell acute lymphoblastic leukemia (B-ALL) cell line, was used as target cells. CAR-T cells were injected into a mice model with or without target cells. Then we measured the distribution of CAR-T cells in mice. In addition, an exploratory clinical trial was conducted in 13 r/r B-cell non-Hodgkin lymphoma (B-NHL) patients, who received CAR-T cell infusion. The dynamic changes in patient blood parameters over ti

SUBMITTER: Ying Z 

PROVIDER: S-EPMC7908740 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature