Increased aperiodic gamma power in young boys with Fragile X Syndrome is associated with better language ability.

ABSTRACT:

Background

The lack of robust and reliable clinical biomarkers in Fragile X Syndrome (FXS), the most common inherited form of intellectual disability, has limited the successful translation of bench-to-bedside therapeutics. While numerous drugs have shown promise in reversing synaptic and behavioral phenotypes in mouse models of FXS, none have demonstrated clinical efficacy in humans. Electroencephalographic (EEG) measures have been identified as candidate biomarkers as EEG recordings of both adults with FXS and mouse models of FXS consistently exhibit alterations in resting state and task-related activity. However, the developmental timing of these EEG differences is not known as thus far EEG studies have not focused on young children with FXS. Further, understanding how EEG diffe

SUBMITTER: Wilkinson CL 

PROVIDER: S-EPMC7908768 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature