PPARγ-p53-Mediated Vasculoregenerative Program to Reverse Pulmonary Hypertension.

ABSTRACT:

Rationale

In pulmonary arterial hypertension (PAH), endothelial dysfunction and obliterative vascular disease are associated with DNA damage and impaired signaling of BMPR2 (bone morphogenetic protein type 2 receptor) via two downstream transcription factors, PPARγ (peroxisome proliferator-activated receptor gamma), and p53.

Objective

We investigated the vasculoprotective and regenerative potential of a newly identified PPARγ-p53 transcription factor complex in the pulmonary endothelium.

Methods and results

In this study, we identified a pharmacologically inducible vasculoprotective mechanism in pulmonary arterial and lung MV (microvascular) endothelial cells in response to DNA damage and oxidant stress regulated in part by a BMPR2 dependent transcription factor compl

SUBMITTER: Hennigs JK 

PROVIDER: S-EPMC7908816 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature