Identification of the hub gene BUB1B in hepatocellular carcinoma via bioinformatic analysis and in vitro experiments.

ABSTRACT:

Background

Hepatocellular carcinoma (HCC) is one of the most commonly diagnosed cancers and the fourth leading cause of cancer-related deaths in the world. Although the treatment of HCC has made great progress in recent years, the therapeutic effects on HCC are still unsatisfactory due to difficulty in early diagnosis, chemoresistance and high recurrence rate post-surgery.

Methods

In this study, we identified differentially expressed genes (DEGs) based on four Gene Expression Omnibus (GEO) datasets (GSE45267, GSE98383, GSE101685 and GSE112790) between HCC and normal hepatic tissues. A protein-protein interaction (PPI) network was established to identify the central nodes associated with HCC. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis of th

SUBMITTER: Fu J 

PROVIDER: S-EPMC7908873 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature